AAV-VECTORED EXPRESSION OF THE VASCULAR NORMALIZING AGENTS 3TSR AND FC3TSR, AND THE ANTI-ANGIOGENIC BEVACIZUMAB EXTENDS SURVIVAL IN A MURINE MODEL OF END-STAGE EPITHELIAL OVARIAN CARCINOMA

AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma

Epithelial ovarian cancer is the deadliest gynecological malignancy.The lack of effective treatments highlights the need for novel therapeutic interventions.The aim of this study was to investigate whether sustained adeno-associated virus (AAV) vector-mediated expression of vascular normalizing agents 3TSR and Fc3TSR and the antiangiogenic monoclon

read more

Cellular Targets of HIV-1 Protease: Just the Tip of the Iceberg?

Human immunodeficiency virus 1 (HIV-1) viral protease (PR) is one of the most ut solution gel for cats studied viral enzymes and a crucial antiviral target.Despite its well-characterized role in virion maturation, an increasing body of research is starting to focus on its ability to cleave host cell proteins.Such findings are apparently in contrast

read more

Economic competition, sustainability, and survival endurance: The extinction of the dodo, the Easter Island case, and the tragedy of the commons effect

A fast developing industry worldwide, tourism demands a monumental extent of resources, and at times devastates and condemns the very own environments that are fundamental arrethe bush balm to the economic survival of organizations and the sustainability of travel destinations.The purpose of the study is to link three established scientific themes

read more

The boron transporter SiBOR1 functions in cell wall integrity, cellular homeostasis, and panicle development in foxtail millet

Boron (B) is an essential micronutrient for vascular plant growth.Both B deficiency and toxicity can impair tissue development in diverse plant species, but little is known about the effect of B on reproductive panicle development and grain yield.In this study, a mutant of Setaria italica exhibiting necrotic panicle apices was identified and design

read more